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Image Search Results
Journal: PLoS ONE
Article Title: Effects of Melanocortin 1 Receptor Agonists in Experimental Nephropathies
doi: 10.1371/journal.pone.0087816
Figure Lengend Snippet: (A) Five different doses of adriamycin, in the range of 5–10 mg/kg, were intravenously injected and the level of albuminuria was measured after 7 days. The urinary albumin-to-creatinine ratio (UACR) increased with increasing levels of adriamycin. (B) Albuminuria at day 7. Treatment with the MC1R agonist BMS-470539 did not reduce the level of albuminuria for the 8 mg/kg adriamycin dose, on the contrary it slightly increased albuminuria for the 10 mg/kg dose (n = 17–19, p<0.05). The unspecific melanocortin receptor agonist α-MSH did not have any significant effect (n = 9, n.s.) compared with untreated adriamycin mice. Results are presented as mean ± SEM.
Article Snippet: An MC1R control peptide antigen (
Techniques: Injection
Journal: PLoS ONE
Article Title: Effects of Melanocortin 1 Receptor Agonists in Experimental Nephropathies
doi: 10.1371/journal.pone.0087816
Figure Lengend Snippet: Gene expression of MC1R in human, rat and mouse kidney tissue.
Article Snippet: An MC1R control peptide antigen (
Techniques: Expressing
Journal: PLoS ONE
Article Title: Effects of Melanocortin 1 Receptor Agonists in Experimental Nephropathies
doi: 10.1371/journal.pone.0087816
Figure Lengend Snippet: Western blotting was performed in order to detect MC1R protein expression in mouse and human tissue. Left panel: incubation with a rabbit polyclonal MC1R antibody (Alomone Labs). Right panel: incubation with MC1R antibody and control blocking peptide antigen (BP) in order to show antibody specificity. A) mouse whole glomerular lysate, B) cultured wild type mouse podocytes and C) a human malignant melanoma cell line A375. MC1R protein expression was detected at the expected size of 37 kDa (left panel).
Article Snippet: An MC1R control peptide antigen (
Techniques: Western Blot, Expressing, Incubation, Blocking Assay, Cell Culture